Studies on the Pantothenic Acid Deficiency (I)

The modification of choline deficiency by simultaneous pantothenic acid deficiency.

It was found recently (1) that feeding a cholesterol-rich diet to pantothenic acid-deficient rats did not result in the fatty livers and high levels of cholesterol in liver and serum seen in comparable animals maintained on a normal diet. Decrease in food intake appeared not to account for this phenomenon, since the food intake of the deficient group on a body weight basis was higher than that ...

The effect of pantothenic acid deficiency on acetylation in rats.

The ability of normal and pantothenic acid-deficient rats to acetylate a foreign substance was compared by injection of p-aminobenzoic acid (PAB) and the subsequent measurement of the acetylated PAB excreted. Young male rats weighing around 100 gm. or mature rats averaging over 300 gm. were used in various experiments. Those selected for pantothenate deficiency were given a purified diet free o...

The Effect of Pantothenic Acid Deficiency on Acetylation in Bats*

The ability of normal and pantothenic acid-deficient rats to acetylate a foreign substance was compared by injection of p-aminobenzoic acid (PAB) and the subsequent measurement of the acetylated PAB excreted. Young male rats weighing around 100 gm. or mature rats averaging over 300 gm. were used in various experiments. Those selected for pantothenate deficiency were given a purified diet free o...

Cholesterol metabolism in pantothenic acid deficiency.

Pantothenic acid deficiency induced in human subjects.

Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a "diet" devoid of pantothenic acid, with omega-methylpantothenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experiments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrit...